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Novartis Institutes for BioMedical Research, Inc.
Computational Chemistry/Biology Research Investigator (Ph.D)
Location: Charlestown,
Massachusetts
02129
Posted on:
9/11/2009 9:42:39 AM
Postion type:
Full time
Job Code:
1679818HHL
Required Education:
Bachelor's Degree
Salary:
Competitive
DESCRIPTION
A position is available for a highly-motivated scientist to join a dynamic group in the department of Center for Proteomic Chemistry/Lead Finding Platform. This is an exciting opportunity to perform cutting-edge research in an industry setting at our Cambridge site. Reporting to the Head of Lead Discovery Informatics you will be responsible for the analysis and development of HTS screening hits using state of the art chemometrics and systems biology approaches.The ideal candidate will possess the following qualifications:
* Ph.D. degree in computational chemistry, computational biology or a related field, with 3+ years of related work experience.
* Familiarity with up-to-date biological screening paradigms.
* A proven track record in leveraging in silico techniques to drive basic science projects or in impacting hit finding activities in a drug discovery environment.
* A solid understanding of chemometrics, which includes QSAR methodologies, data mining and visualization, protein modeling, molecular docking, library design, conformational analysis, pharmacophore development, 2D and 3D similarity.
* A good understanding of bioinformatics and computational biology including gene expression data analysis and mining biological pathways to enhance target knowledge (GeneGO, Ingenuity).
* Demonstrate the ability to work independently as effectively as being able to collaborate in multidisciplinary teams.
* Strong analytical and problem-solving skills and scientific creativity are essential.
* Excellent oral and written communication skills and organizational skills are required.
The following qualifications are a plus:
* A solid experience in a pharmaceutical or biotech environment.
* Background in medicinal chemistry and basic knowledge of synthetic organic chemistry.
* Programming skills in C/C++/C#, Java and scripting in Perl/Python and Pipeline Pilot.
REQUIREMENTS:
See Job Description
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