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Astellas Pharma US, Inc.
Research Associate Antibody Production, Agensys - Santa Monica, CA
Location: Santa Monica,
California
00000
Posted on:
3/20/2009 12:54:36 PM
Postion type:
Full time
Job Code:
404872
Required Education:
Salary:
DESCRIPTION
At Agensys, we're changing tomorrow by moving oncology forward. We¡¦ve developed a pipeline of novel therapeutic fully human monoclonal antibodies (MAbs) to treat solid tumors based on our own proprietary targets. We have discovered and validated a portfolio of clinically relevant targets in 14 different cancer types. Our pipeline includes therapeutic MAbs to multiple cancer indications that are at different stages of clinical and pre-clinical development. Our parent company, Astellas Pharma US helps us shine. Together we are the bright spot in the pharmaceutical industry ¡V not just because of what we do, but in the way we do it. If you are looking for a company where you can change a life, make a dream come true, and light the way for a better tomorrow, this is the place for you. RESEARCH ASSOCIATE ANTIBODY PRODUCTIONThe qualified candidate will be a member of a versatile and highly skilled team dedicated to the development, production and evaluation of monoclonal antibodies. A major requirement will be the application of mammalian cell culture techniques to optimize monoclonal antibody production in both WAVE and stirred tank bio-reactors ranging in size from 1L to 100L. This position will involve growing and transfecting mammalian cells and harvesting culture supernatants isolated from both adherent and suspension adapted cell lines. The work scope may also involve optimization of processes, preparation of DNA and performance of ELISAs and other analytical assays designed to assess cell health and productivity in bioreactor runs. To be successful in this position, the incumbent will need excellent aseptic technique and the ability to perform work in a careful and meticulous manner. In addition there will be a requirement to assist with the purification of monoclonal antibodies for pre-clinical research and development
REQUIREMENTS:
?X Bachelors, or Masters Degree in Cellular Biology, Bioengineering, Microbiology or a related field. ?X Minimum of 2 years post graduate experience. ?X Extensive mammalian tissue culture experience, preferably gained in an antibody production environment. ?X Knowledge of process development for antibody production from hybridomas or recombinant cells; experience with techniques to improve recombinant protein expression by stable mammalian cell lines is advantageous?X Applicants should be well organized, self-motivated, and capable of working independently and in a collaborative environment. ?X Experience in antibody purification techniques is desirable but not essential as full training will be given.?X Excellent verbal and written communication?X Excellent organizational skills. ?X Meticulous note keeping will be essential
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