Rare Gene Variants Making Drug Discovery Difficult, University of Washington

5/18/2012 8:29:48 AM

Rare DNA mutations are so plentiful in the human genome that they make it difficult to precisely identify the genetic switches that cause many common human diseases, two studies found. The data, released yesterday in the journal Science, shows that the vast majority of genetic variations found in people are rare and evolutionarily recent. Well-known DNA variations that are common across large populations probably don’t widely affect many illnesses, the authors said.

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